晚期妊娠妇女尿脱氧吡啶啉与尿肌酐比值的测定及临床意义

Measurement and clinical significance of the ratio of urine deoxypyridinoline and urine creatinine in late normal pregnant women

目的 了解正常晚期妊娠(晚妊)妇女尿脱氧吡啶啉(deoxypyridinoline,DPD)和尿肌酐(creatinine,Cr)比值(DPD/Cr)及其与骨钙代谢关系。方法 测定80例正常晚妊妇女(late normal pregnant women,LPW)及22例正常非孕妇女(normal nonpregnant women,NPW)尿DPD、尿Cr和血钙离子浓度(serum calcium,SCa),并计算DPD/Cr。尿DPD浓度用化学发光法测定。结果 晚妊妇女尿DPD/Cr比值明显增高,与正常非孕妇女比较,差异有显著性(P<0.001),晚妊妇女SCa与正常非孕妇女比较略有下降,但差异无显著性(P>0.05)。结论 尿DPD/Cr较SCa能更准确、灵敏、特异地反映体内缺钙状况,是孕期保健中值得推荐的骨钙代谢监测指标。

Objective To investigate the ratio of urine deoxypyridinoline (DPD) and uring creatinine (Cr) (DPD/Cr) in late normal pregnant women (LPW) and the relationship between DPD/Cr and bone calcium metabolism. Methods The parameters, DPD/Cr and serum calcium comcentration (SCa) were measurde in 80 LPW and 20 normal non-pregnant wome (NPW). DPD was detected by chemoluminescent immunoassay (CLI-A). Results Urine DPD/Cr in LPW group was significantly higher than that in NPW group (P<0. 001) but SCa level did not show significant difference between these two groups (P>0. 05), although SCa level lowered slightly in LPW group. Conclusion Urine DPD/Cr could reflect lack of calcium within body more sensitively, accurately and specifically than SCa, and may be used as a valuable parameter to detect bone calcium metabolism during pregnancy.