先天性胫骨假关节的组织病理学研究

Histopathological study of congenital pseudarthrosis of the tibia

目的 探讨先天性胫骨假关节 (CPT)的发病部位及病理特点 .方法 对 2 8例 CPT不同部位的 70个标本进行了大体显微镜及电镜观察 .结果 CPT骨膜及断端间有大量的致密纤维结缔组织增生 ,压迫和侵蚀胫骨 .病变组织由大量高分化纤维母细胞、少量肌纤维母细胞和大量胶原纤维构成 .未见异常神经成分 .结论 CPT是一种起源于骨膜的纤维瘤病所造成的病理性骨折、骨不连 。

AIM To investigate the pathological changes and origin of congenital pseudarthrosis of tibia (CPT). METHODS Seventy different specimens were taken from 28 CPT patients. By macroscopy, microscopy, electronic microscopy all specimens were studied after fixation and dyeing. RESULTS The soft tissue interposed dense connective tissues were proliferated between the CPT bone ends and periosteum which compressed and eroded the tibia. There were a large number of cellular components and collagen fibers in the proliferated dense connective tissues, including plenty of fibroblast myofibroblast and some indifferential cells, but no evidence of neuro fibers were found. CONCLUSION The pathological fracture or non union of CPT is caused by the fi bromatosis, which has a strong activity of cellular proliferation and corrosion. CPT is a disease of non neuro origin. Its occurrence has no direct relation with neurofibromatosis.