内皮素对大鼠睾丸间质细胞睾酮生成的影响

Effect of endothelin-1 on testosterone production by rat leydig cells in vitro

本研究采用大鼠睾丸间质细胞体外培养的技术 ,观察了内皮素 1对离体间质细胞睾酮分泌的影响。研究发现 ,10 -9mol/L的ET 1可显著抑制间质细胞睾酮的基础分泌 (P <0 .0 5 ) ,并且ET 1对人绒毛膜促性腺激素 (hCG)刺激睾丸间质细胞睾酮分泌也有抑制作用 ,其有效抑制浓度为 10 -10 mol/L(P <0 .0 5 )。本实验结果提示 ,ET 1呈剂量依赖性抑制睾丸间质细胞睾酮的基础分泌和hCG诱导的分泌 ,ET

The effect of ET?1 on testosterone production by rat leyding cells in vitro was studied.The results indicated that ET?1 might significantly inhibit the basal testosterone production (10 -9 mol/L, P <0.05) and hCG induced testosterone secretion (10 -10 mol/L, P <0.05) of rats'leydig cells in vitro.This study suggests that ET?1 probably is an intratesticular regulatory factor.