CFTR突变基因不影响先天性梗阻性无精子症患者ICSI治疗的成功率

CFTR mutations have no effect on results of ICSI in congenital obstructive azoospermia patients

为探讨囊性纤维化跨膜转运调节物 (CysticFibrosisTransmembraneConductanceRegulator,CFTR)基因突变是否影响先天性梗阻性无精子症患者单精子卵浆内注射 (IntracytoplasmicSpermInjection ,ICSI)治疗的成功率 ,本文对3例先天性梗阻性无精子症CFTR突变基因携带者和 18例CFTR突变基因非携带者进行了ICSI的治疗。结果表明 :先天性梗阻性无精子症CFTR突变基因携带者与CFTR突变基因非携带者ICSI治疗时受精率、卵裂率和妊娠率无显著性差异。结论 :CFTR突变基因并不影响先天性梗阻性无精子症患者ICSI治疗的成功率 ,故这些患者在ICSI治疗前夫妻双方更有必要行CFTR突变基因的筛查。

To investigate whether CFTR mutations have a effect on results of ICSI in obstructive azoospermia patients,ICSI procedure was performed in 3 CFTR mutations carriers and 18 non CFTR mutations carriers respectively.No difference are found in fertilization rate,cleavage rate and pregnancy rate following ICSI for CFTR mutations carriers as compared to non CFTR mutations carriers.CFTR mutations have no effect on results of ICSI,it is neccessary for Chinese congenital obstructive azoospermia patients and their wives to screen for CFTR mutations prior to ICSI.