亚硒酸钠和维生素C的协同抗突变作用

Effect on Synergic Antimutation of Sodium Selenite and Vitamin C

目的 观察亚硒酸钠和维生素C在拮抗烹饪油烟凝集物 (COF)的致突变作用方面的表现。 方法 在人外周血淋巴细胞培养物中注入一定剂量的亚硒酸钠或一定剂量的维生素C来观察淋巴细胞的姐妹染色单体交换率 (SCE率 )。 结果 亚硒酸钠可显著降低COF处理过的淋巴细胞SCE率 ;终浓度 0 9× 10 7mol/L的亚硒酸钠和 90 9ug/ml的维生素C在降低COF处理过的淋巴细胞SCE率方面存在着极显著的协同效应。 结论 一定剂量的亚硒酸钠和维生素C在拮抗COF的致突变性过程中存在着极显著的协同效应 ;

Objective To observe the effecton synergic antimuthtion of sodium selenite and vitamin C cooking oil fumes. Methods SCE(siter chromatid exchanges)were observed and contrasted before and after addition of sodium selenite or vitamin C to the culture of human blood lymphocytes. Results Sodium selenite may lower SCE of lymphocytes;sodium selenite(0.9×10 7 mol/L) and vitamin C(90.0ug/ml) have a very significant synergistic effect on lowering SCE of lymphocytes treated by COF.Conclusions A certain amount of sodium selenite and vitamin C have a synergistic effect on antimutation to COF;sodium selenite alone also lower SCE of human blood lymphocytes.