超生理剂量十一酸睾酮影响精子发生动态研究

Dynamic Study on the Effect of Over-Physiological Dosage of Testosterone Undecanoate on the Spermatogenesis

目的 :探讨超生理剂量十一酸睾酮 (TU)用于男性避孕的效果及预后。方法 :正常生育史男 12例 ,每月肌肉注射TU 1次 ,共 3次 ,通过精液常规分析 ,对精子密度及生精细胞密度进行动态检测。停药后每 2个月检测 1次 ,共 3次。结果 :用药后精子密度和生精细胞密度较用药前显著下降 (P <0 .0 1) ;停药后精子密度和生精细胞密度逐渐恢复 ,期间有反跳现象。结论 :TU具有显著抑制精子发生的作用。TU作为男性激素避孕药安全、有效。

To study the effect of over physiological dosage of testosterone undecanoate(TU)in male contraception, 12 males with normal fertility were given im TU once every month for 3 times. The sperms were routinely examined for density of sperms or spermatogenic cells. After withdrawal of the treatment, the patients were examined once every two months for 3 times. Our results showed that the density of sperms or spermatogenic cells were significantly lower than before the treatment. After withdrawal of the treatment, the density of sperms of spermatogenic cells gradually recovered and it rebound during this period. It is concluded that TU has obvious spermatogenesis inhibiting effect and as a male contraceptive, it is safe and effective and its effect is reversible.