小儿肺炎心衰患者血浆降钙素基因相关肽和血管紧张素Ⅱ的含量变化及意义

The Changes of Calcitonin Gene Related-peptide and AngiotensinⅡ in Children with Pneumonia Complicated Heart Failure and Significance

目的 探讨降钙素基因相关肽 (CGRP)和血管紧张素Ⅱ (ATⅡ )在婴幼儿肺炎心衰中的作用。方法 采用放射免疫法检测各组 (肺炎并心衰组、肺炎组和对照组 )血浆CGRP和ATⅡ水平 ,同时测定肺炎心衰时动脉血氧分压(PaO2 )。结果 ①肺炎心衰患儿血浆CGRP水平低于对照组和普通肺炎组 (P <0 .0 1) ;肺炎心衰组ATⅡ高于对照组和肺炎组 (P <0 .0 1) ,且肺炎组亦高于对照组 (P <0 .0 1)。②肺炎心衰患儿心衰纠正后CGRP和ATⅡ趋于正常。③肺炎心衰患儿血浆CGRP与PaO2 成正比 (P <0 .0 5 ) ,ATⅡ与PaO2 成反比 (P <0 .0 5 )。结论 CGRP和ATⅡ在婴幼儿肺炎心衰发病中起重要作用。

Objective To research the effect of caleitonin pene related-peptide(CGRP) and angiotensinⅡ(ATⅡ) in pathogenesis of pneumonia complicated with heart failure in children.Method The authors detected plasma CGRP and ATⅡ lends by radioimmunoassay in groups, and measured arterial partial oxygen pressure in those children with pneumonia complicated with heart failure.Result ①CGRP level in patients with pneumonia complicated with heart failure is significantly lower than that in patients with pneumonia and control (P<0.01), while ATⅡ level is significantly higher than that in patients with pneumonia and controls, respectively (P<0.01), moreover, ATⅡ level in patients with pneumonia is also higher than that in controls (P<0.01). ②As the children recovered from heart failure through medicine CGRP and ATⅡ levels tended to normal level. ③In patients complicated with heart failure, CGRP level had a positive correlation with arterial oxygen pressure, and ATⅡ had a negative with arterial oxygen pressure. Conclusion CGRP and ATⅡ play a important role in pathogenesis of heart failure in patients with pneumonia.