爆震后豚鼠耳蜗残存螺旋神经节细胞的分布特点及超微结构改变

The distribution characteristics and ultrastructural changes of residual cochlear spiral ganlion cells after blast exposure in guinea pigs

目的 探讨爆震后豚鼠耳蜗残存螺旋神经节细胞分布特点及超微结构改变。方法 复制爆震致聋豚鼠模型．取耳蜗做病理检查，观察耳蜗残存螺旋神经节细胞分布特点及其超微结构变化。结果 爆震组２１ｄ的耳蜗螺旋神经节细胞在耳蜗中轴切片的二下部位为（２７．０±６．９）个；而正常对照组耳蜗中轴切片的二下部位为（５１．０±４．７）个，两组间统计学差异有显著意义。豚鼠螺旋神经节细胞透射电镜观察爆震组震后 ３ ｄ出现明显线粒体肿胀，线粒体峙断裂；２１ｄ后线粒体数量明显减少，且有畸形。而同期的正常对照组未发生上述现象。结论 爆震后耳蜗螺旋神经节细胞数量减少，残留神经细胞线粒体超微结构有明显病变。

Objective To study the distribution characteristics and ultrastructural changes of residual cochlera spiral ganlion cells after blast exposure. Methods Guinea pig ear blast injury models were made. The cochlear spiral ganlion cell counting and ultrastructural observation were carried out in two groups of animals after 3d and 21d of blast exposure. Results The number of spiral ganlion cells in blast group was less than that in normal control group after 2Id of blast exposure. Significant mito-chondria swollen was observed after 3d of blast exposure and abnormal mitochondria was still observed after 21d of blast exposure. There was no abnormality in normal control group. Conclusions After blast exposure. there were ultrastructural as well as reduction of the number of cochlear spiral ganlion cells in the experimental animals.