环丙沙星对慢性阻塞性肺疾病患者氨茶碱药物动力学的影响

Effects of Ciprofloxacin on pharmacokinetics of aminophylline in patients with chronic obstructive pulmonary disease

目的 量化地研究环丙沙星对慢性阻塞性肺疾病患者氨茶碱药物动力学的影响。方法 8例慢性阻塞性肺疾病患者口服氨茶碱 (10 0 mg,8h1次 )后加服环丙沙星 (5 0 0 mg,12 g1次 ) ,用紫外分光光度计平行监测合用前后茶碱的经时血药浓度 ,拟合茶碱药物动力学参数并做统计学比较。结果 与合用前相比 ,患者血清中茶碱浓度显著增高 (P <0 .0 5 ) ,消除半衰期非常显著地延长 (P <0 .0 1) ,消除率下降 (P <0 .0 5 )。结论 合用环丙沙星对氨茶碱的消除动力学有显著性抑制 ,临床合用时应注意茶碱的血浓度监测 。

objective To study quantitatively the effects of ciprofloxacin on the pharmacokinetics of aminophylline and to offer clinic pharmacological inference of the concomitant oral administration of aminophylline with each of Ciprofloxacin Methods 8 patients were given Aminophylline orally 100 mg Q8 h,added Ciprofloxacin 500 mg from 3 days The serum concentration of sequent minute before and after combination was determined by UV spectrophototmetry The pharmacokinetic parameters and statistical analysis were finished by computer Result The serum concentrations of aminophylline of patients increased remarkably (P<0 05),and the elimination half life prolonged remarkably (P<0 01),the elimination ratio decreased remarkably (P<0 05) Conclusion The effect of ciprofloxacin on the pharmacokinetics of elimination phase of aminophylline is considerable in human,and it suggests that is clinically necessary to detect the serum concentration of aminophylline while administrated concomitantly with ciprofloxacin to prevent patients' poisoning