饮食行为与前列腺癌相关性病例对照分析

A case-control analysis of diet and risk of prostate cancer

目的 分析不同食物的食用频度或习惯与前列腺癌发生的相关关系。方法 设计饮食频度调查表 ,并采用以医院为基础的频数配比病例对照研究方法 ,对 186例经组织病理学或细胞学检查确诊的前列腺癌患者及按频数配比要求选配的2 36例对照者的饮食情况进行了调查。结果 主食大米、喝牛奶、猪肉、禽肉、蛋类、萝卜、青绿菜及豆类食品等与前列腺癌发病危险性的高低有统计学关联 (P <0 .0 5 ) ;将饮食因素同时引入模型进行多因素逐步非条件Logistic回归分析 ,显示喝牛奶、猪肉、蛋类的食用频度与前列腺癌危险性的增加有关 (P <0 .0 5 ) ;水果、青绿菜、豆类食品的食用频度则与前列腺癌危险性的降低有关联 (P <0 .0 5 ) ;未发现鱼类、动物肝脏、牛羊肉、喜食咸、喜食辛辣食物等食物的食用频度或习惯与前列腺癌有关。

Objective To investigate the relationship between the di et habits an d the risk of prostate cancer.Method A hospital-based fr equency-matched case-control study was conducted for a total number of 149 pat ients with prostate cance r and 236 matched controls.All the subjects were interviewed with an identical s elf-administered food frequency questionnaire.Results Multivariate stepwise unco nditional logistic regression analysis showed that the diet frequency of milk co nsumption,pork and eggs were independent risk factors of prostate cancer. Fruits ,green, vegetables and bean products were the independently protective factors o f prostate cancer.The results of linear trends test showed that the significant dose (food frequency)effects relationships between the diet frequency of milk co nsumption, eggs,green vegetables,bean products,poultry meat or radish and the ri sk of prostate cancer were exist. No association was found between diet frequenc y and/or habits of eating fishes,animal liver,beef or mutton,to be fond of salt y or pungent food and the risk of prostate cancer. Conclusions The study results provided some valuable clues and evidence for further st udy of the relationship between foods or components and risk of prostate cancer in Chinese.