直肠癌根治术后行多动脉联合化疗对预防复发和转移的价值

The preventive effect of multi-arterial chemotherapy on recurrence and metastasis of rectal cancer after radical resection

目的 观察肠系膜上动脉、髂内动脉及肝固有动脉联合化疗对直肠癌根治性切除术后患者肿瘤复发和转移的预防效果。方法 随机选取 10 3例直肠癌根治性切除术后患者分为两组 ,治疗组 5 6例 ,以肠系膜上动脉、髂内动脉及肝固有动脉为靶血管 ,采用介入导管技术分别注入化疗药物 :5 氟尿嘧啶 +丝裂霉素C +顺铂。对照组 47例 ,术后采用全身静脉化疗 ,用药同治疗组。治疗后每组均随访 5年 ,观察术后 1～ 5年内肿瘤复发和转移的部位及数量。结果 治疗组 5年内共复发和转移 18例 ,复发和转移率为 32 .1% ( 18/ 5 6) ,对照组复发和转移共 2 2例 ,复发和转移率为 47.0 %( 2 2 / 47) ,两组复发和转移率相比差异显著 (P <0 .0 1)。结论 肠系膜上动脉、髂内动脉及肝固有动脉联合化疗对直肠癌根治性切除术后患者肿瘤复发和转移有预防作用。

Objective To evaluate the preventive effect of chemotherapy via superior mesentery artery,internal iliac artery and propria hepatic artery on recurrence and metastasis of rectal cancer after radical resection.Methods One hundred and three cases were randomized into two groups.Fifty-six cases of rectal cancer after radical resection were treated by chemothreapy via the arteries with 5-Fu,MMC and DDP.Forty-seven cases in control group were treated with the same drugs via vein.The rate of recurrence and metastasis were followed up for five years.Results The rate of recurrence and metastasis was 32.1%(18/56), 47.0%(22/47) respectively in treated group and control group with difference(P<0.01).Conclusion The preventive effect of multi-arterial chemotherapy on recurrence and metastasis in rectal cancer after radical resection is confirmed.