初治涂阳肺结核的耐药监测

Surveillance of drug resistance of pulmonary tuberculosis in Ningbo of Zhejiang province

目的 建立以WHO指南为基础的结核病细菌学耐药监测系统 ,掌握宁波市初治涂阳肺结核的耐药水平。 方法 采用整群抽样方法于 1999年 10月至 2 0 0 0年 3月选择全市所有新发涂阳病例 ,并对其全部培养阳性的菌株进行菌型鉴定及 4种抗结核药物 (INH、SM、RFP、EMB)的耐药测试。 结果 初治耐药率为 17.87% ,初治耐多药率为 3 .40 % ;耐药率高低与病人的性别、年龄无关 (P >0 .0 5 )。 结论 宁波市结核病的初治耐药率处于较高水平 。

Objective To establish the surveillance system for drug resistance of pulmaonary tuberculosis according to WHO guideline and to evaluate the initial drug resistance in Ningbo. Methods Cluster sampling technique was applied to continuously select all the patients with smear positive pulmonary tuberculosis from October 1999 to March 2000. Identification and susceptibility tests were done in all culture positive samples. Results The initial drug resistance was 17.87%, initial multi drug resistance 3.40%, and there were no statistical relationship of the initial drug resistance rates among the sex and age (P>0.05). Conclusion The initial drug resistance of tuberculosis ranks high in Ningbo of Zhejiang province, and the tuberculosis control program of Ningbo should be further strengthened.