胃癌组织内微血管密度的意义

The significance of intratumoral microvessel density in gastric carcinoma

目的 探讨胃癌组织微血管密度(MVD)与胃癌类型、分化程度及与淋巴结转移的关系。方法 采用血管内皮细胞特异标志物CD34对53例不同类型的胃癌组织进行免疫组化染色及光镜观察。 结果 ①高分化腺癌、低分化腺癌、未分化癌平均MVD(个/mm2)分别为96.04、144.87、164.22,三者间的差异具有统计学意义(P<0.05);②组织学Ⅰ级、Ⅱ级、Ⅲ级的平均MVD(个/mm2)为86. 23、116.25、156.84,经统计学处理,差异有显著性(P<0.05);③平均MVD(个/mm2)有淋巴结转移者为126.36，无淋巴结转移者为94.14，两者间的差异具有显著性（P<0.05）；④MVD与肿瘤大小及浸润深度无明显关系。结论 MVD与胃癌的分化程度、组织学类型及淋巴结转移有关，可作为临床上判断胃癌患者预后的一个独立指标。

Objective To investigate the relationship betwe en intratumoral microvessel density (MVD) and the histologic type, degree of dif ferentiation, especially, lymph node metastases in gastric carcinoma. M ethods 53 cases of different gastric carcinoma histology were observed t hrough microscopy and immumohistochemical staining using special marker CD34. Results ①MVD( mm-2) in high, low-and non-differentiat ed glandocarcinoma were 86.04, 144.87, 164.22, respectively. The difference b etween them was significant (P<0.05). ②MVD(mm-2) in different hi stology grade Ⅰ, Ⅱ, Ⅲ was 86.23, 116.25, 156.84 respectively, the difference be tween hemt was highly significant (P<0.05). ③MVD(mm-2) in cases with lymph node metastases was 126.36, while MVD in cases without lymph node metast ases was 94.14, the difference was significant (P<0.05). ④MVD in cases w as not significant in tumur size and infiltrating depth. Conclusion Intratumoral MVD is closely related to degree of differentiation, histolog y type and lymph node metastases. It is an independent prognostic marker.