摘要
我国混凝土结构设计规范的安全设置水准与国际通用标准之间存在着相当大的差距。现行规范采用的可靠度设计方法并没有使结构的安全性有所改善 ;相反 ,这一方法本身尚需改进和探讨。增加结构设计的安全性需要从结构构件承载能力的安全度、结构整体牢固性和结构耐久性等多方面努力 ,这三者都应提高 ;考虑到我国的国情 ,设计规范的安全设置水准还应适当考虑人为差错的不利影响。工程设计人员在结构的安全性上更应考虑业主与使用者的要求和利益 ,并向他们负责 。
As compared to design codes of practice in developed countries,the safety margin of structural members set in the Chinese Building Code for Concrete Structures is rather low.The adoption of the reliability design method for the code does not improve the safety margin,on the contrary,the method itself needs to be modified and updated.To enhance the structural safety,efforts shall be made in aspects such as structural robustness and durability as well as safety margin for structural members.Besides,the effect of human error on safety requirements should be take into account considering the particular background of construction workers in China.For design engineers,they should pay more attentions to meet the owner and user interests with respect to the structural safety,and try to adapt themselves to variety of changes brought about by economic style transitions in recent years.Key words:structural design;concrete structure;code of practice;safety factor;reliability design method;durability rounding nontumor liver tissues. The expression rate of GPC3 mRNA in large tumor (>5 cm) was significantly higher than that in small tumor (≤5 cm, 79.31% vs 41.67%, P <0.01). The expression rate of GPC3 mRNA in poorly differentiated HCC was significantly higher than that in well differentiated HCC (76.47% vs 42.86%, P <0.05). The expression of GPC3 mRNA was not correlated with age, sex, HbsAg seropositivity, fibrocapsule, portal venous embolus and intrahepatic metastasis. No GPC3 mRNA was detected in non hepatocellular carcinoma. Conclusion GPC3 gene was specifically overexpressed in AFP negative HCC, indicating that GPC3 gene might be a new genetic marker of HCC and play important roles in hepatocarcinogenesis.
出处
《建筑技术》
北大核心
2001年第10期682-687,共6页
Architecture Technology
