异丙酚对猕猴失血性休克复苏血浆内皮素和降钙素基因相关肽的影响

THE EFFECT OF PROPOFOL ON THE CONTENT OF ENDOTHELIN AND CALCITONIN GENE-RELATED PEPTIDE IN THE MONKEYS WITH HEMORRHAGIC SHOCK AND RESUSCITATION

观察异丙酚对猕猴失血性休克并复苏血浆内皮素 (ET)和降钙素基因相关肽 (CGRP)的影响。 12只失血性休克并复苏模型的猕猴随机分为异丙酚组和对照组 ,对照组不用异丙酚 ;异丙酚组在放血前用计算机靶控技术使猴血浆异丙酚浓度达到 8mg/L并维持此水平。分别于放血前、失血性休克 2h和复苏 2h时抽取血标本 ,用放免法测定血浆ET和CGRP含量。结果显示 ,异丙酚组在失血性休克 2h和复苏 2h时CGRP水平和CGRP/ET比值较对照组明显升高 ,且复苏 2h时异丙酚组ET水平较对照组低。提示在失血性休克并复苏的猕猴 ,异丙酚能增加机体血浆CGRP含量 。

To investigate the effect of propofol on the plasma contents of endothelin(ET) and calcitonin gene related peptide(CGRP).Twelve monkeys with hemorrhagic shock were divided randomly into two groups.The monkeys in propofol group(PG) were administered propofol to 8mg/L plasma concentration by target control infusion with computer,while monkeys in control group(CG) were not .Venous blood were collected to determine plasma ET and CGRP contents by radioimmunoassay before bleeding, 2 hours after hemorrhagic shock and 2h after resuscitation. Compared with control group,the CGRP level and CGRP/ET of PG were significantly increased at 2h after hemorrhagic shock and 2h after resuscitation,while ET level of PG at 2h after resuscitation was significantly lower than that of CG. These findings indicate that propofol can increase the plasma content of CGRP and decrease the plasma content of ET in monkeys after hemorrhagic shock and resuscitation, and ET may play an important role in the development of hemorrhagic shock.