雄激素受体对结直肠癌预后的意义

SIGNIFICANCE OF ANDROGEN ERCEPTOR IN PROGNOSIS OF PATIENTS WITH COLORECTAL CANCER

为探讨雄激素受体对结直肠癌病人的预后意义 ,作者以放射配基结合分析法测定结直肠癌及癌旁粘膜AR水平 ,结合 30例病人年龄、性别、肿瘤部位 (结、直肠 )、分化程度 (高、中、低 )、Dukes分期 (A、B、C、D)以及结直肠癌DNA及CEA水平 ,与随访结果一起纳入生存资料的Cox回归模型分析。结果显示 ,直肠癌较结肠癌预后差 (P <0 0 1)。Dukes分期与生存期呈负相关 (P <0 0 1)。结直肠癌旁粘膜AR水平与病人生存期呈正相关 (P <0 0 5 )。其他因素如性别、年龄、分化程度、癌组织AR、DNA及CEA水平与生存期不相关。提示结直肠癌旁粘膜AR水平为结直肠患者生存的保护性因素 。

To investigate the relation between AR and the survival period in patients with colorectal cancer.Multiple variance Cox regression analysis was performed between AR, DNA and CEA in tumor tissues and normal mucosa, and other host and tumor characteristics, such as gender, age, location of tumor (colon, rectum), degree of differentiation (high, middle, low), Dukes stage (A,B,C,D) and the survival period, in 30 colorectal patients. There were no significant differences with regard to gender, age, histological differentiation, AR, DNA and CEA levels in tumor tissues. Rectal carcinoma had poorer prognosis than colon carcinoma ( P <0 01). There was statistically significant negative orrelation between Dukes stages and survival length ( P <0 01), and positive correlation between AR of normal mucosa near colorectal carcinoma and survival length ( P <0 05). We concluded that AR level in normal mucosa near colorectal carcinoma was a significant independent predictor of survival period in patients with colorectal cancer.