血液滤过在移植肾功能延迟恢复治疗中的应用

Clinical study of hemofiltration in the treatment of delayed graft function

目的探讨血液滤过在治疗移植肾功能延迟恢复(DGF)中的应用.方法分析比较了1999年1月～2001年6月间26例DGF病人分别应用血液滤过和血液透析的疗效.结果 26例病人分别进行了132例次血滤和153例次血透,在血液滤过治疗过程中病人低血压的发生率(5.3%,7/132)显著较血液透析(20.3%,31/153)低(P＜0.01);术后感染发生率分别为7.7%(1/13)和28.6%(4/13)(P＜0.05);移植肾功能恢复的时间分别是(17.69±8.42)d和(25.62±10.15)d(P＜0.05).结论血液滤过对DGF是一种较好的治疗方法.

 Objective To study the effect of hemofiltration in the treatment of delayed graft function (DGF) after renal transplantation. Methods During the period from January, 1999 to June, 2001, 26 patients with renal transplantation underwent hemofiltration or hemodialysis for DGF management (n=13 in each group), and the therapeutic effects of these 2 approaches were compared. Results Altogether 132 times of hemofiltration and 153 times of hemodialysis were performed. Hypotension occurred in 5.3% patients receiving hemofiltration, a rate significantly lower than that of patients with hemodialysis (20.3%, P<0.01). One patient undergoing hemofiltration while 4 patients undergoing hemodialysis (P<0.01) acquired infection posto- peratively, and the former group of patients had shorter period for graft function recovery than that of the latter (17.69±8.42 d vs 25.62±10.15 d, P<0.05). Conclusion Compared with hemodialysis, hemofiltration might be a better therapeutic alternative for DGF management.