急性缺血性中风早期中小剂量溶拴治疗的凝血指标观察

OBSERVATION ON THE INDEXES OF THROMBOXANE DURING THROMBOLYSIS OF ACUTE IS CHMIC STROKE WITH MID-MINIDOSE OF UROKINASE

目的 :研究急性缺血性中风早期溶栓治疗的凝血指标的变化 ,以指导临床治疗。方法 :测定 18例溶栓患者不同时间的凝血酶时间 (TT)、凝血酶原时间 (PT)、激活的部分凝血活酶时间 (APTT)、纤维蛋白原 (FIB)、血小板 (PL T) ,观察其动态变化及其与临床的关系。结果 :TT溶栓前为 (12 .73± 2 .8) s,溶栓后为 (14.78± 3.4) s,1d后为 (14.72± 1.89) s;PT溶栓前为 (13.5 9± 2 .95 ) s,溶栓后为 (17.74± 3.4) s,1d后为 (16 .5 8± 1.9) s;APTT溶栓前为 (2 0 .2 2± 3.5 9) s,溶栓后为 (2 4.39± 5 .14) s,1d后为 (2 4.49± 4.0 8) s,经统计学检验 ,均有显著性差异。FIB无显著改变。PL T溶栓前为(2 73.8± 114.7)× 10 9/ L,溶栓后为 (2 13.4± 6 7.4)× 10 9/ L,1d后为 (2 0 3.9± 93.4)× 10 9/ L。溶栓前后比较 ,差异有显著性。结论 :中小剂量天普洛欣尿激酶 (UK)溶栓后 TT、PT、 APTT延长 ,PL T数量减少 ,但是病人无出血现象发生 ,此疗法比较安全。

Objective:To study the changes of thromboxane index es during thrombolytic treatment with mid-minidose at the early stage of acute cerebral ischemic stroke Methods:To determine thrombin time, prothrombin time, activated partial thrombopilastin time,fibrinogen and platelet at different time of thrombolysis and observe their dynamic changes as well as the relationship between the changes and clinical phenomenon Results: Thrombin time was (12 73±2 8)s before thrombolysis,but it was eongated to (14 78±3 4 )s immediately after thrombolysis, and to (14 72±1 89)s one day after thrombolysis The prothrombin time was elongated from (13 59±2 95)s before thrombolysis to (17 74±3 4)s immediately after thrombolysis and to (16 58±1 9)s one day after thrombol ysis The activated partial thrombopilastin time was also elongated from (20 22±3 5 9)s before thrombolysis to (24 39±5 14)s immediately after thrombolysis and to (2 4 49±4 08)s one day after thrombolysis The results indicate that the function of fibrinolysis was enhanced and that the state of thromboxane was low Fibrinogen h ad no significant difference The number of platelet was reduced from (273 8±114 7)×10\+9/L before thrombolysis to (213 4±67 4)×10\+9/L immed iately after thrombolysis and to (203 9±93 4)×10\+9/L one day after thrombolysis Conclusion:Although the indexes of thromboxane changed(thrombin time,prothrombin time and activated partial thrombopilastin time were elongated and the number of platelet was reduced after thrombolysis with mid-minidose of UK), the patients had no hemorrhage, which indicates the safety of this therapy