二氧化硫吸入对大鼠血红细胞的氧化损伤作用

Oxidation Damage of Sulfur Dioxide Inhalation on Erythrocytes of Rats

目的 为了研究低浓度二氧化硫 (SO2 )毒理作用的机理。方法 测定 SO2 (14 mg/ m3)吸入对大鼠血红细胞抗氧化酶活性和脂质过氧化水平的影响。结果 SO2 吸入可引起超氧化歧化酶 (Cu、Zn- SOD)活性降低、谷胱甘肽过氧化物酶 (GSH- Px)活性升高、过氧化氢酶 (CAT)活性无明显改变 ,以及红细胞脂质过氧化水平显著升高。结论 SO2 通过产生活性氧自由基引起脂质及其它生物大分子的氧化损伤 ,可能是低浓度 SO2 毒理作用的主要机制。

Objective The aims of the present study are to further investigate mechanism of toxicological role of sulfur dioxide (SO 2) exposure on mammalian animals Methods Effects of SO 2 inhalation (14 mg/m 3) on activities of antioxidative enzymes and levels of lipid peroxidation in erythrocytes of male rats were determined Results SO 2 inhalation caused the decrease of Cu,Zn SOD activity,the increase of GSH Px activity,and no change of CAT activity,and the increase of level of lipid peroxidation in rat erythrocytes Conclusion Primary mechanism of toxicological role of SO 2 exposure at low concentrations may be that oxidation damages of lipid and other biological large moleculars are caused by SO 2 producing reactive oxygen species