摘要
气道慢性炎症是变应性哮喘的基本特征 ,也是气道高反应性发生的病理基础。辅助性T淋巴细胞 (Th细胞 )之Th1细胞因子释放减少、Th2细胞因子上调表达导致体液免疫应答过强 ,是诱发慢性气道炎症的关键因素。白细胞介素 10具有抑制多种细胞 (Th1、Th2、单核巨噬细胞 )合成释放促炎性细胞因子的功能 ,并且参与气道高反应性的形成 ,其产生也受到炎性介质组胺等细胞因子外因素的调节。
Allergic asthma is characterized by chronic airway inflammation,on which airway hyperresponsiveness(AHR) is based pathophysiologically.The excessive humoral immunologic response,caused by decreased expression of T helper type?1(Th1) cells and increased expression of T helper type?2(Th2) cells,is the key evoked factor of chronic airway inflammation.Interleukin?10(IL?10) may inhibit some kinds of cells(Th1,Th2,monomacrophages) from synthesizing and releasing proinflammatory cytokines.In addition,IL?10 is involved in the development of AHR.The production of IL?10 is affected by inflammmatory mediators,such as histamine.
出处
《东南大学学报（医学版）》
CAS
2001年第3期196-199,共4页
Journal of Southeast University(Medical Science Edition)
基金
铁道部科技基金资助项目 (60 4 760 0 0 4 5)
关键词
白细胞介素-10
哮喘
炎症
气道高反应性
组胺
interleukin 10
asthma
inflammation
airway hyperresponsiveness
histamine
