摘要
目的观察普罗帕酮 (心律平 )终止阵发性室上性心动过速 (PSVT)的即时疗效及安全性。方法 3 7例 PSVT,静脉注射普罗帕酮70 mg,于 5分钟完成 ,观察 2 0分钟 ;未终止者重复用 70 mg,再观察 3 0分钟 ,仍未终止者再用 70 mg。用药前、后和 PSVT终止时 ,记录血压、心率及 12导联心电图。结果显效 75 .7% (2 8/ 3 7) ,有效 2 1.6% (8/ 3 7) ,总有效率 97.3 %。起效时间 1~ 5 5 (7.1± 2 .8)分钟。普罗帕酮平均累积量 10 5 mg。部分患者可出现轻度血压下降 ,P-R间期、QRS时限及 QTc间期延长 ,一过性 度 型窦房阻滞及头晕、恶心等副作用 ,未经处理逐渐消失。结论普罗帕酮静脉注射终止 PSVT有效、快速。
Objective To observe the clinical efficacy and safety of propafenone on paroxysmal supraventricular tachycardia (PSVT).Methods 37 patients with PSVT were injected with 70 mg propafenone intravenously in 5 minutes.The unrecovered patients in 20 minutes were injected with 70 mg propafenone intravenously again,who were given 70 mg propafenone intravenously once again if not controlled in late 30 minuted.Blood pressure,heart beat,12 lead electrocardiogram were recorded before and after use of drug.Results The significant effective rate was 77.5% and effective rate was 21.6% with overall effective rate of 97.3% and effective time of 1~55 (7.1±2.8) minutes.The average accumulated dose of propafenone was 105 mg.Some side effects were observed in part of patients,including slight reduction of blood pressure,P R interval.QRS wave and Q T interval prolonged,temporary type sino atrial block,vertigo and nausea,etc whice could vanish gradually if not treated.Conclusion Propafenone by intravenous injection can quickly contro PSVT with saftey and effectiveness.
出处
《中国综合临床》
北大核心
2001年第7期498-499,共2页
Clinical Medicine of China