术前介入化疗对宫颈癌Ⅱ_b远期疗效的观察

Long-term results of preoperative interventional chemotherapy for cervical carcinoma in stage Ⅱ_b

目的研究巨块型宫颈癌 b期术前介入化疗加血管栓塞的远期疗效。方法术前介入化疗加血管栓塞组 (A组 )及术前放疗组 (B组 ) ,治疗后 2～ 4周两组患者均行广泛全子宫加盆腔淋巴结清扫术。结果 A、B两组的 3年生存率分别为 91.0 1%、88.48% ,5年生存率分别为 81.79%、73 .3 7% ,A组复发率 2 1.7%低于 B组 48.6% (P<0 .0 5 ) ,两组并发症均可治愈。结论两组生存率无明显差异 ,但术前介入化疗加血管栓塞可明显降低术后复发率 ,尤其是腺癌患者 ,延长无瘤生存期 。

Objective To study the effectiveness of interventional chemotherapy in combination with embolization for bulky cervical carcinoma in stage Ⅱb.Methods Cases divided into preoperative interventional group(A)and preoperative radiotherapy group(B).Radical surgery for uterine and pelvic lymph node was performed in each group 2～ 4 weeks after treatment.Results The 3 year survival rates were 91.0% and 88.48%,and 5 year survival rates were 81.79% and 73.37% in A and B,respectively.The recurrence rates were 21.7% in A and 48.6% in B(P<0.05).Complications could be controlled in A and B.Conclusion There is no significant difference between two groups,but preoperative interventional chemotherapy combined with embolization can reduce the recurrence rate and improve the patients ,quality of survival,especially the patients with glandular cancer.