心力衰竭患者内皮素及降钙素基因相关肽的改变

Changes of plasma endothelin and calcitonin gene related peptide in patients with congestive heart failure

目的 探讨充血性心力衰竭 (CHF)患者血浆内皮素 (ET )和降钙素基因相关肽(CGRP)含量及其在CHF发生、发展中的作用。方法 采用放射免疫分析法测定 42例CHF患者血浆ET及CGRP的水平。结果 对照组的血浆ET和CGRP分别为 (5 0 .83± 7.5 0 )pg/ml及 (5 6 .77± 16 .0 6 ) pg/ml;CHF患者的血浆ET和CGRP分别为 (5 9.71± 17.2 6 )pg/ml及 (46 .5 2± 12 .2 9)pg/ml,与对照组比较 ,CHF患者的血浆ET显著增高 ,CGRP显著降低 ,且与心力衰竭的严重程度相关 ,经强心、利尿、扩血管等综合治疗 ,心功能改善后 ,CHF患者的血浆ET降低 ,CGRP升高。结论 CHF患者的血浆ET含量增高 ,CGRP含量降低 ,且与病情严重程度相关 ,与治疗前相比 ,心力衰竭纠正后 ,ET降低 ,CGRP升高。

Objective To determine the levels of plasma endothelin(ET) and calcitonin gene related peptide(CGRP) in patients with congestive heart failure(CHF) and their action in development of CHF.Methods The plasma ET and CGRP in 42 patients and 28 healthy controls were measured by radioimmunoassary.Results The level of ET was significantly higher in patients (59.71±17.26) pg/ml than that in controls (50.83±7.50) pg/ml;the plasma CGRP was obviously lower in patients (46.52±12.29) pg/ml than that in controls (56.77±16.06) pg/ml.The increased plasma ET and decreased plasma CGRP were associated with the degree of CHF. Conclusions There are an increased level of plasma ET and a decreased level of plasma CGRP in CHF patients and they are associated with the degree of CHF.ET and CGRP may play an important role in development of CHF.