肾功能衰竭患者血清铁蛋白的变化

Ferritin level in acute and chronic renal failure

目的 探讨急、慢性肾功能衰竭 (肾衰 )患者血清铁蛋白浓度的变化及其意义。方法 随机选择 70例肾功能衰竭患者 ,分为急性肾衰组 (A组 ,35例 )和慢性肾衰组 (B组 ,35例 ) ,并选择 30名正常人 (C组 )和 2 0例急性上呼吸道感染者 (D组 )作对照 ,测定血尿素氮 (BUN)、血清肌酐 (Scr)、红细胞压积 (Hct)、血红蛋白 (Hb)、血清铁蛋白 (SF)和血清铁 (SI)水平。结果 A组SF水平明显高于B组和C组 (P <0 .0 0 1) ,B组与C组SF比较差异无显著性 (P >0 .5 )。结论 急性肾衰患者血清铁蛋白明显增高 。

Objective To evaluate the ferritin level in both acute and chronic renal failure and try to establish a novel differential criterion between them. Methods Thirty five patients with acute renal failure and 35 patients with chronic renal failure were randomly selected. They were divided into group A and group B. Thirty healthy individuals were employed as controls ( group C), and 20 patients with acute infections as group D. The levels of serum urea nitrogen (BUN),serum creatinine (Scr), hematocrit (Hct), hemoglobin(Hb), serum ferritin(SF) and serum iron(SI) were measured among them. All data were analyzed by unpaired student t test. Results The SF level in group A was significantly higher than that in group B or C (P<0.001); And SF level was not obviously different between group B and C (P>0.5). Conclusion The SF level is elevated in patients with acute renal failure. However, it does not obviously change in patients with chronic renal failure.