2型糖尿病Leptin与胰岛素抵抗的关系

Investigation of relationship between leptin and insulin resistance in type 2 diabetes mellitus

目的 研究新诊断非肥胖 2型糖尿病患者血清leptin水平与胰岛素抵抗的相关关系。方法 以空腹血浆胰岛素与血糖乘积的倒数作为胰岛素抵抗程度的指标 ,采用酶联免疫法测定 31名正常人、2 9例新诊断非肥胖 2型糖尿病患者的血清leptin水平。 结果 新诊断非肥胖 2型糖尿病患者 ,血清leptin浓度与胰岛素敏感性指数有显著负相关 (r =-0 .37,P <0 .0 5 ) ,主要表现在男性 (r =-0 .6 6 ,P <0 .0 1)。leptin与空腹血胰岛素 (r =-0 .45 ,P <0 .0 5 )、空腹血糖(r =-0 .37,P <0 .0 5 )有正相关关系。男性患者leptin血清水平比正常男性有显著性升高 (P<0 .0 5 )。结论 新诊断非肥胖 2型糖尿病患者血清leptin水平与胰岛素抵抗程度有显著正相关关系 ,leptin与

Objective To study the relationship between serum leptin concentration and insulin resistance in newly diagnosed nonobese type 2 diabetic patients. Methods The reverse of the product of fasting plasma glucose and insulin(IAI) was used as a parameter to evaluate the degree of insulin resistance. The serum leptin concentrations were measured in 31 normal subjects and 29 newly diagnosed nonobese type 2 diabetic patients by ELISA. Results In newly diagnosed nonobese type 2 diabetic patients , there was a significant negative correlation between serum leptin concentration and IAI(r=-0.37,P<0.05), especially in male(r=-0.66,P<0.01).leptin was positively associated with fasting serum insulin(r=-0.45,P<0.05),and fasting blood glucose(r=-0.37,P<0.05).The serum leptin levels were significantly higher in male patients than in normal men(P<0.05).Conclusion There is a significant positive correlation between serum leptin concentration and the degree of insulin resistance in newly diagnosed nonobese type 2 diabetic patients. The leptin plays an important role in pathogenesis of type 2 diabete mellitus.