Ⅰ型和Ⅱ型TGF-β受体在人增生性瘢痕和瘢痕疙瘩中表达的研究

The Expression of Transforming Growth Factor β Receptors in Human Hypertrophic Scars and Keloids

运用免疫组化技术检测增生性瘢痕 ( HTS)和瘢痕疙瘩 ( KS)中 型 ( R )和 型 ( R ) TGF- β受体的表达和分布情况 ,了解 TGF- β受体在人 HTS和 KS形成中的作用。结果发现 ,HTS成纤维细胞 ( Fb)表面 R 和 R 有阳性表达 ,而且随着病程的延长 ,受体表达逐渐减弱 ,直至消失 ;KS浸润部 Fb表面 R 和 R 呈强阳性表达 ,中央部未见受体表达阳性的 Fb;正常皮肤 Fb表面受体表达阴性。提示在 HTS形成过程中 ,不仅 TGF- β增高 ,Fb表面 型和 型 TGF- β受体也增高 ,使 TGF- β作用放大 ;TGF- β及其受体可能与 KS的浸润性生长有关。

In order to investigate the role of TGF-β receptors in the formation of hypertrophic scar (HTS) and keloid (KS), the expression and distribution of TGF-β receptors type Ⅰ (RⅠ) and type Ⅱ (RⅡ) in HTS and KS was examined by immunohistochemistry. It was found that RⅠand RⅡ were expressed on the surface of fibroblasts (Fb) in HTS. Moreover, with the delay of the disease course, the expression of RⅠand RⅡ on the Fb was reduced gradually; The Fb on which RⅠand RⅡwere highly expressed were assembled in the invasive part of KS, while RⅠand RⅡwere negative in the center part of KS. TGF-β receptors were not detectable on the Fb of normal skins. It suggests that during the formation of HTS not only TGF-β but also their receptors on the Fb are increased. The latter makes the the biologic action of TGF-β to be enlarged collaboratively. TGF-β and their receptors may play an important role in the invasive growth of KS.