食管鳞癌γ-连接蛋白和钙粘附蛋白表达及其预后意义

Expression of γ-Catenin and E Cadherin in Esophageal Squamouo Cell Cancer and its Prognosis Significance

目的 :研究食管鳞状细胞癌γ 连接蛋白 (γ catenin ,γ cat)和钙粘附蛋白 (E cadherin ,E cad)的表达及临床病理学意义。方法 :采用免疫组织化学方法检测 62例食管鳞癌手术标本γ cat、E cad蛋白表达 ,并结合临床随访资料进行分析。结果 :γ cat阳性病例 4 7例 (75 8% ) ,E cad阳性病例 39例(62 9% )。γ cat蛋白缺失表达与淋巴结转移有关 (P <0 0 5 ) ;肿瘤分化程度、术后生存期在γ cat、E cad蛋白缺失表达组与保留表达组比较 ,差异有显著性 (P <0 0 5 )。结论 :γ cat缺失表达易出现淋巴结转移 ;γ cat、E cad缺失表达是食管癌预后差的因素之一。

Objective To investigate the Expression of γ catenin and E cadherin in esophageal cancer and its clinicopathology.Methods γ catenin and E cadherin expression were examined immunohistochemically in 62 cases of esophageal cancer and clinical dated were analyzed.Results The expression rate of γ catenin,E cdherin were 75 8%,62 9% respectively.The expression of γ catenin was related to lymph nodes metastasis of tumors( P <0 05).the expression of γ ctenin and E cadherin were related to degree of tumor grade and survive time.Conclusions The loss expression of γ catenin is closely correlated to lymph node metastasis.the loss expression of E cadherin and γ catenin are correlation to poor survive times in esophageal cancer which may serve as a parameter for determining tumor biological behavior and prognosis.