冠脉病变与血尿酸水平相关性分析

ANALYSIS OF THE RELATIONSHIP BETWEEN THE SEVERITY OF CORONARY LESIONS AND SERUM URIC ACID

目的 :探讨血尿酸与冠脉病变的关系。方法 :对冠心病及非冠心病人进行病例对照研究。结果 :冠心病人的血尿酸水平显著高于非冠心病人 ;血尿酸水平与冠脉病变记分呈显著正相关 ;以冠脉病变记分为因变量的多元回归分析未显示血尿酸与冠脉病变记分的独立相关性 ;以血尿酸为因变量的多元回归分析发现冠脉造影结果 (阳性为 1,阴性为 0 )对血尿酸却有独立的正相关影响。结论 :血尿酸与冠状动脉粥样硬化有关 ,可能是间接地通过其它危险因素的作用促进动脉粥样硬化。

Objective:To sutdy the relationship between the severity of coronary lesions and serum uric acid(UA).Methods:The cases and the control patients who had a coronary angiography underwent a case-control study.Results:The levels of serum UA in case group were significantly higher than the controls;Serum UA strongly correlated with the severity of coronary lesions;Through multiple stepwise regression analysis where the coronary severity scores was the dependent variable,serum UA didn't enter the regression equation that indicated serum UA didn't have an independent relationship with coronary lesions.The results of coronary angiography (positive=1,negative=0) entered the regression equation where the dependent variable was UA,which probably demonstrated that elevated serum UA may be a marker of severe coronary atherosclerosis.Conclusions:Maybe serum UA indirectly correlated to coronary athersclerosis,their relationship and the mechanism needs to further study.