Grave患者^(131)I治疗前后血清细胞间粘附分子-1水平的研究

SERUM LEVELS OF ICAM-1 BEFORE AND AFTER ^(131)I-TREATMENT OF GRAVE'S DISEASES

目的 :探讨ICAM - 1在Grave(GD)病发病中的作用。方法 :应用ELISA法测定GD患者131I治疗后不同时期血液ICAM的水平 ,并与正常对照组比较。结果 :Grave病 1周后 ,ICAM - 1明显升高 ,并与FT3、FT4 成正相关 ,6个月后ICAM - 1显著低于治疗前组 ,但仍高于正常组。Grave眼病 (GO)患者血清ICAM - 1水平明显高于GD病人 ,而有甲亢患者ICAM - 1明显高于无甲亢患者。结论 :ICAM - 1能动态反映GD的情况。在GO早期 。

Objective:To assess the serum levels of ICAM-1 before and after 131 I-treatment of Grave's disease.Methods:We measured the serum levels of ICAM-1 of 0,1w,6M by ELISA method.Results:1. Significent increases were seen in free T 4 index(FT 41),free T 3 index(FT 31)within the first weeks,and TSH simultaneously decreased.2. The serum levels of ICAM is significant higher in GO than in non-GO and in hyperthrodism than in non-hyperthrodism.Conclusions:The elevated serum concentration of ICAM-1 in patient with GD probably reflects ongoing immune processes.