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正常人及闭角型青光眼患者小梁细胞凋亡流式细胞学研究

The study of apoptosis in trabecula cells in normal and angle closure glaucoma
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摘要 目的 :研究正常人及闭角型青光眼患者小梁细胞凋亡发生率及与眼压升高的关系。方法 :采用Apo 2 .7分子探针 ,使用流式细胞仪检测 2 2例正常人及 2 7例闭角型青光眼小梁细胞凋亡发生率。结果 :正常人小梁细胞Apo2 .7分子检出率为 (2 .0 1± 0 .68) %。闭角型青光眼发作期检出率为 (5 .2 5± 0 .89) % ,两者差异有高度显著性 (P <0 .0 1) ,正常人小梁细胞Apo2 .7因子检出率与年龄增长无相关性 (r =0 .2 9) .闭角型青光眼小梁细胞Apo2 .7因子检出率与眼压升高呈显著性正相关 (r=0 .77) .结论 :正常人小梁细胞存在细胞凋亡发生 ,与年龄增长无相关 ,闭角型青光眼小梁细胞凋亡明显增加 ,与眼压升高呈正相关。 Objective:To study the apoptosis of trabecula cells in normal and angle closure glaucoma(ACG) and to explore the relationship between the rate of apoptosis and intra-ocular pressure(IOP)in ACG.Methods:The Apo2.7 had been determinated with flow cytometry in 22 examples of normal trabecula tissues and 27 examples of trabecula tissue of ACG.Results:The occurrence rate of Apo2.7 was (2.01±0.68)% in normal trabacula tissue.The rate of Apo2.7 was (5.25±0.89)%in ACG. The difference between normal and ACG was significant difference( P <0.01).There had no relationship between the rate of Apo2.7 in normal trabecula tissue and age ( r =0.29).There was positive relationship between the rate of Apo2.7 and IOP in ACG( r =0.77).Conclusion:The apoptosis of trabecula tissue in normal person has no relationship with the increase of age,while the increase of apoptosis of trabecula tissue has positive correlation with the elevating of IOP.
出处 《山东医大基础医学院学报》 2001年第5期283-284,共2页
关键词 小梁细胞 凋亡 青光眼 流式细胞学 Trabecula cells Apoptosis Glaucoma
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  • 1Guo YJ,Cancer Res,1994年,54卷,422页
  • 2尹格平,中华物理医学杂志,1992年,14卷,增刊,20页

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