血液病毒标志物两次检测模式的探讨

Investigation on the Mode of Double Testing of Blood for Virus Markers

目的 探讨血液两次检测的意义和作用。方法 调查统计部分采供血机构 1999年 7～ 12月常规血液检测的结果 ,并追踪随访两次检测结果不一致的献血者 ,采集其半年后的标本复检 ,对可疑标本用NAT作进一步的检测。结果 总两次检测不一致率为 0 .6 3% ,绝大部分两次检测结果不一致的标本为假阳性。结论 目前通过两次检测不能显著提高血液质量。应通过提高试剂总体质量和实施NAT检测来进一步显著提高输血安全。

Objective To probe into the significance and role of double testing of blood for virus markers.Methods The data on the results of routine blood testing at some blood centers in China from July to December,1999 were gathered and analysed.The blood donors with inconsistent results during the double testing were followed up and their blood samples were collected at least half a year later.Nucleic acid amplification testing(NAT) was performed on the samples.Results Only 0.63% of the donors showed inconsistent results during the double testing.Most of the positive results were false positive.Conclusion The double testing currently implemented does not help significantly improve the quality of the blood supply.It is important to enhance blood safety further by improvement of quality of the reagents and introduction of NAT.