重组生长激素与人血清白蛋白治疗肝硬化低蛋白血症的疗效比较

Comparison of Effects of Recombinant Human Growth Hormone and Human Serum Albumin in the Treatment of Liver Cirrhosis with Hypoproteinemia

目的 :比较应用重组人生长激素 (rhGH)和人血清蛋白 (HSA)治疗肝硬化低蛋白血症的疗效。方法 :分别对 6 6例住院肝硬化患者应用rhGH4 5U皮下注射 ,每天 1次 ,共 10次 ,或 2 0 %HSA5 0mL ,静脉滴注 ,每天 1次 ,共 10次。在治疗前后动态观察临床表现和检测各项肝功能指标。结果 :无论应用rhGH或HSA ,患者在治疗后精神、睡眠、食欲都有好转 ,腹胀减轻 ,腹水和下肢浮肿消退或减轻。ALT和AST明显下降 ,肝功能恢复正常。白蛋白含量有明显的升高达至正常水平。结论 :和HSA比较 ,rhGH治疗肝硬化低蛋白血症同样有较好的疗效 ,能明显提高白蛋白含量并有较长的疗效 ,费用较低 。

Objective:To compare the effects of recombinant human growth hormone (rhGH) and human serum albumin(HSA) in the treatment of liver cirrhosis with hypoproteinemia.Methods:66 patients with liver cirrhosis with hypoproteinemia were divided into two groups.33 patients(groupⅠ) were subcutaneously given rhGH in the dosage of 4.5IU per day for 10 days.The other 33 patients(group Ⅱ) were given 50 mL of 20% human serum albumin iv,drip,qd for 10 days.The clinical manifestations and some indicators of liver function were compared before and after the treatments.Results:After the treatments,the clinical manifestations in both group of patients were improved.ALT and AST significantly decreased.The level of serum albumin increased to normal level and the liver function restored to normal.Conclusion:rhGH is effective in the treatment of liver cirrhosis with hypoproteinemia,which is comparable to the effect of HSA,with a longer lasting effect,lower cost and rare side effects.