诱导自体移植物抗宿主病的自体外周血干细胞移植治疗恶性肿瘤

GVHD Following Autologous Peripheral Blood Stem Cell Trasplantation Reduced Malignancy Relapse

Administration of the immunosuppressive drug cyclosporine(CSA) after autologous peripheral blood stem cell transplantation(APBSCT) induces a systemic auto-immune syndrome resembling graft-versus-host disease(GVHD), this syndrome termed autologous GVHD has significant antitumor activity, it can reduce the incidence of tumor relapse after APBSCT. The antitumor effect of this auto-aggression syndrome can be enhanced by the administration of γ-interferon(γ-IFN). Five consecutive patients who received APBSCT received therapy inducing autologous GVHD. Intravenous administration of CSA〔1 mg/(kg·d) for 28 days〕 was begin on the day of transplantation. γ-interferon(0.025 mg/m 2 qod) was administered sub-cutaneously from days 7 throngh 28 after transplatation. Results showed that four of five occured autologous GVHD-skin demage, five in control didn′t occur autologous GVHD. The relapse rate of the treated cases was 20%(1/5) versus 60%(3/5) of the control, and the median survival time of the treated cases was 20(4-30) months versus 10(2-20) months of the control. The data indicates that autologous GVHD results in low relapse rate of the patients rececving APBSCT.