摘要
目的 :研究慢性染铅大鼠血铅与血清SOD、MDA的时间变化效应 ,探讨SOD、MDA在铅中毒中的变化。方法 :SOD活性测定采用亚硝酸盐显色法 ,MDA含量测定采用硫代巴比妥(TBA)法。结果 :低剂量染铅大鼠血清SOD活力在 6 0天以后低于对照组 (P <0 0 5 ) ,高剂量染铅组SOD活力 30天以后明显低于对照组 (P <0 0 5 )。高剂量染铅组MDA含量 30天以后明显高于对照组 (P <0 0 5 )。结论 :慢性染铅过程中 ,SOD活性随染铅时间延长逐渐降低 ,MDA含量随染铅时间延长逐渐增加。
Objective:To investigate the changes of super oxide dismutase (SOD) activity and malondialdehyde (MDA) content in serum of rats exposed to excess lead following the time.Methods:SOD activity in serum was measured by nitrat coloration and MDA content by TBA method. Results:Compared with control group, the activity of SOD in blood was markedly lower in low-dose group after 60 days , and 30 days in high-dose group (P <0 05). MDA level in blood of control group was significantly lower than the high-dose group after 30 days. Conclusion:During chronic lead poisoning , lead can lead to the decrease of SOD activity and the increase of MDA content as time goes by.
出处
《武警医学院学报》
CAS
2001年第3期189-191,共3页
Acta Academiae Medicinae CPAPF
基金
武警医学院科研基金资助(WY 98-0 5 )
