宁夏大肠腺癌危险因素探讨:123例大肠腺癌1∶1配对研究

An Investigation on Risk Factors of Colorectal Adenocarcinoma in Ningxia: Paired Case-control Study of 123 Cases.

应用条件logistic回归分析方法对宁复123名大肠腺癌现患病例的危险因素进行了探讨。数据表明:饮用大口浅井水和山涧水及窖水,具有肠息肉和溃疡性结肠炎病史、痔疮或(新鲜)血便史、习惯性便秘史是本地区大肠腺癌的危险因素,其标准回归系数均大于1.96,OR值依次为1.40、3.07、2.59、13.00,常食葱蒜(2/3以上的配餐中使用葱,且有吃生蒜或腌蒜习惯)为负相关因素,标准回归系数和OR值分别为～1.95和0.66。各常见次食因素、肿瘤家族史、其它慢性病史、烟酒嗜好等因素与大肠腺癌的发生之间,未发现有明显的统计学关联。

A study on risk factors of 123 Ningxia prevalent colo-rectal adenocarcinoma (CRAC) cases with histopadsthological diagnosis was conducted in 1979, using the methods of questionnaries and conditional logistic regression. Data shown suggested that the risk factors significantly related to CRAC might include the drinking of wide mouth shallow well water, mountain stream water, and pit water, (STD(Bk)=1.97, OR=1.40; a clinical history of intestinal polyps and ulcerative colitis, (STD(Bk)=3.35, OR=3.07; clinical history of hemorrhoids or bloody stool, (STD (Bk)=3.46, OR=2.59; and clinical history of habitual constipation, (STD(Bk)=2.47, OR=13. Reversely, a habit of eating green onion and garlic frequently might be a protective factor of CRAC,STD(Bk)=1.95, OR=0.66.