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乳酸左氧氟沙星滴眼液在兔眼房水中的药代动力学 被引量:1

Pharmacokinetics of Levofloxacin Lactate Eye-drops in Aqueous Humor of Rabbits
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摘要 目的 :测定乳酸左氧氟沙星 (LVFX)滴眼液单次滴眼后不同时间兔眼房水的药物浓度 ,计算其药动学参数。方法 :取32只大白兔分为8组 ,各组于用药后0 125、0 25、0 50、0 75、1 0、2 0、3 0、4 0h取眼房水 ,用高效液相色谱法测定药物浓度。结果 :用3p87药动学程序拟合符合一室开放模型 ,药物在房水中Tmax0 940h、Cmax 0 592μg/ml、T1/2(Ka)0 479h、T1/2(Ke)0 919h。结论 :单次滴眼后兔房水中LVFX峰浓度均高于大多数致病菌的MIC90,LVFX滴眼液可用于眼内感染的临床治疗和预防。 OBJECTIVE:To measure the concentrations of levofloxacin in aqueous humor after a single eye dripping of drug and calculate the pharmacokinetic parameters.METHODS:32 rabbits were divided into 8 groups.The rabbit eyeballs were enucleated to make a collection of aqueous humor at 0.125,0.25,0.5,0.75,1.0,2.0,3.0 and 4.0 hours after dripping.All measurements were performed with HPLC.RESULTS:In aqueous humor,Tmax:0.940h,Cmax:0.592μg/ml,T1/2(Ka):0.479h,T1/2 (Ke)0.919h.By using 3p87 pharmacokinetic program,the concentration-time curves were fitted as one-compartment op_en model.CONCLUSION:All the concentrations of levofloxacin at different times after dripping in aqueous humor exceeded the minimum inhibitory concentration for 90%(MIC90)of most bacterial pathogens.These results show that levofloxacin lactate eye-drops may be an effective antimicrobial agent for the treatment and prevention of intraocular infections as well as other ocular infections.
出处 《中国药房》 CAS CSCD 2001年第8期456-457,共2页 China Pharmacy
关键词 左氧氟沙星 兔眼 房水 药代动力学 高效液相色谱法 levofloxacin rabbit eye pharmacokinetics HPLC
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  • 1[1]Cochereau Massin I, Bauchet J, Faurisson F, et al. Ocu-lar kinetic of pefloxacin after intramuscular administra-tion in albino and pigmented rabbits, Antimicrobial[J].Agents Chemotherapy, 1991, 9(6):1 112.
  • 2[2]Akkan AG, Multlu L, Ozyazgan S, et al. Penetation oftopically applied ciprofloxacin, norfloxacin and ofloxai-ng into the aqueous humor of the uninflamed human eye[J]. Chemother, 1997, 9(4):257.
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