ANP基因G664A多态性与出血性脑卒中的关系

The Relationship between G664A Polymorphism of ANP Gene and Hemorrhagic Stroke

目的 了解心房利钠肽 (ANP)基因G6 6 4A多态性与中国人群出血性脑卒中之间的关系。方法 利用PCR和分子杂交技术对该位点在北京地区出血性脑卒中患者 (12 1人 )中的分布进行了检测和分析 ,并与无脑血管病变的人群 (10 4人 )进行比较。结果 中草药国人群G6 6 4A多态性分布符合Hardy Weinberg遗传平衡定律 ,但在脑出血患者和无脑血管病变者中分布无差异。结论 ANP基因G6 6

Object To evaluate the relationship between the G664A polymorphism of atrial natriuretic polypeptide(ANP) gene and the hemorrhagic stroke in Chinese population.\ Methods\ 121 patients with hemorrhagic stroke and 104 controls without stroke were surveyed by polymerase chain reaction(PCR) and corresponding probe hybridization. Results The G664A polymorphism was coincided with Hardy Weinberg equilibrium, but neither the prevalence rates of genotypes nor allele frequencies were significantly different between stroke cases and controls. Conclusion\ The G664A polymorphism of ANP gene may not be a genetic risk of hemorrhagic stroke in Chinese population.