乳源ACE抑制剂(降血压肽)的研究现状

Studies on the Antihypertensive Peptides Derived from Dairy

利用酶或微生物水解牛乳蛋白质可获得ACE抑制剂 (降血压肽 ) ,近来从乳酸菌发酵的酸奶中也找到了ACE抑制肽 ;经动物实验证明 ,口服一定量的ACE抑制肽或含有ACE抑制肽的酸奶可降低血压 ,而且对血压正常者没有影响。文章中综述了来源于乳蛋白质和发酵乳制品的ACE降血压肽的最新研究进展 。

Antihypertensive peptides are obtained from milk protein by enzyme or microorganism treatment and also found in protease treated cheese whey protein,cheese,sour milk and yogurt like products fermented by some lactic acid bacteria.After oral administration of certain angiotensin I converting enzyme inhibitory peptides(ACEIP)or the sour milk,the potent effect depressing blood pressure was observed to spontaneously hypertensive rats(SHR),but ACEIP had no effect in normotensive rats.Researches on ACEIP derived from milk protein and fermented dairy products are reviewed in this article,and their wide developmental prospects are forecasted.