氟喹诺酮类药联用黄连素治疗细菌性痢疾的疗效观察

CLINICAL EFFICACY OF FLUOROQUINOLONES COMBINED WITH BERBERINE FOR THE TREATMENT OF BACILLARY DYSENTERY

目的 观察氟喹诺酮类药联用黄连素对细菌性痢疾的临床疗效。方法 将 31 6例粪便培养阳性的细菌性痢疾患者随机分为 6组 ,应用氟哌酸 (NFX)、氟嗪酸 (OFX)、环丙氟哌酸 (CPFX)单用及分别联合黄连素进行治疗 ;各组疗程均为 3～ 5d。结果 NFX组、NFX +黄连素组、OFX组、OFX +黄连素组、CPFX组、CPFX +黄连素组的治愈率分别为 61 .82 %、80 .95 %、73 .40 %、91 .1 1 %、92 .45 %、98.0 4 % ,细菌清除率分别为 65 .45 %、87.30 %、75 .51 %、91 .1 1 %、90 .57%、1 0 0 .0 %。

Objective To observe the clinical effect of flurooquinolone (FQ) combined with berberine for the treatment of 316 patients with bacillary dysentery. Methods 316 cases with bacillary dysentery of positive stool culture were divided into 6 groups at random, and they were treated with Norfloxacin (NFX), NFX+Berberine, Ofloxacin (OFX), OFX+Berberine, Ciprofloxacin (CPFX), CPFX+Berberine respectively. The period of treatment of all groups was 3～5 days. Results The curative rates of NFX, NFX+Berberine, OFX, OFX+Berberine, CPFX and CPFX+Berberine were 61.82%, 80.95%, 73.40%, 91.11%, 92.45%, 98.04% respectively, and the bacterial clearance rates of all groups above were 65.45%, 87.30%, 75.51%, 91.11%, 90.57%, 100.0% respectively. Conclusion Berberine may increase the curative effect of FQ in the treatment of bacillary dysentery.