CVB感染在上海地区小儿常见疾病发病中的地位及年龄特点

SIGNIFICANCE AND AGE CHARACTERISTICS OF COXSACKIE VIRUS B INFECTIONS AMONG COMMON DISEASES OF CHILDREN IN SHANGHAI

为探讨柯萨奇B组病毒 (CVB)感染在上海地区小儿常见疾病发病中的地位及年龄特点 ,作者对96 7例住院患儿进行了血清CVB抗原 (CVB Ag)及CVB特异性IgM抗体 (CVB IgM )的检测。结果发现 ,上呼吸道感染组、下呼吸道感染组、心肌炎组、哮喘组、ITP组、过敏性紫癜组CVB Ag及CVB IgM阳性率均高于对照组 ,0～ 1岁组及 1～ 3岁组CVB阳性者主要是呼吸道感染患儿 ,此后随年龄增长 ,阳性者中呼吸道感染者逐渐减少 ,心肌炎比例逐渐上升 ,同时 ,过敏性紫癜、ITP患儿的比例亦上升 ,而哮喘在各年龄组均占一定比例。结果提示除呼吸道感染外 ,CVB在小儿心肌炎、哮喘、ITP。

To investigate the significance and age characteristics of CVB infections among common diseases of children.CVB Ag and CVB IgM were detected from the sera in 967 children in hospital. Positive rates of CVB Ag and CVB IgM in the upper respiratory tract infection group, the lower respiratory tract infection group, the myocarditis group, the asthma group, the ITP group and the anaphylactoid purpura group were higher than the control group.Most of the children with positive CVB were in the 0～1 year age group and 1～3 years age group had respiratory tract infection. With increasing age,the number of the children with respiratory tract infection gradually decreased,while number of the children with myocarditis,asthma,ITP and anaphylactoid purpura increased in those children with positive CVB. It suggests that, beside respiratory tract infection,CVB plays an important role in pathogenesis of myocarditis,asthma,ITP and allergic purpura in children.