CD44v6蛋白在舌鳞癌组织中的表达及其意义

EXPRESSION AND SIGNIFICANCE OF CD44v6 PROTEIN IN SQUAMOUS CELL CARCINOMA OF THE TONGUE

探讨舌鳞癌中CD44v6蛋白的表达及其对舌鳞癌进展和转移的影响。应用常规ABC免疫组织化学染色技术检测 40例舌鳞癌组织中CD44v6的表达 ,其中包括无淋巴结转移 2 4例及有淋巴结转移 16例 ,舌乳头状瘤 12例及正常舌粘膜组织 9例。结果显示 ,舌鳞癌组织中CD44v6阳性率为 72 5 % (2 9/ 40 ) ,有淋巴结转移者CD44v6高表达的阳性率为 81 3 % (13/ 16 ) ,无淋巴结转移者CD44v6高表达的阳性率为 41 7% (10 / 2 4) ;舌乳头状瘤中仅有 2例阳性高表达 ,阳性率为 16 7% (2 / 12 ) ;而正常舌粘膜组织中未见有CD44v6蛋白的表达。研究表明 ,对舌鳞癌组织进行CD44v6蛋白的检测 。

To study the expression and significance of CD44 splice variant V6 in squamous cell carcinoma of the tongue. The expression levels of CD44v6 protein were determined immunohistochemically in 40 squamous cell carcinoma of the tongue specimens (24 non metastatic primary tumors and 16 metastatic lymph nodes), 12 squamous cell papilloma and 9 normal tongue mucosa using murine exon V6 specific monoclonal antibody. The CD44v6 overexpression was detectable in 29 of 40 squamous carcinoma of the tongue, in 2 of 12 squamous cell papilloma, in 0 of 9 mormal mucosa, P <0 05. The positive rate of high expression in lymph node metastasis (81 3%, 13/16) was markly higher than that in non lymph node metastasis (41 7%, 10/24), P <0 05. However, the expression of CD44v6 was not related with sex, age, location, size and histological type of carcinoma. Determination of CD44v6 protein might be useful in assessing tumor progression and lymphatic metastasis.