Nm23-H1基因表达与非小细胞肺癌转移的关系

The correlation between expression of nm23-H1 gene and metastasis of non-small cell lung cancer.

目的 探讨nm2 3 H1基因表达与非小细胞肺癌 (NSCLC)转移的关系。方法 应用免疫组织化学SABC方法对 90例NSCLC组织标本进行nm2 3 H1表达的检测。结果 NSCLC的nm2 3 H1阳性表达率 5 1 1% (46 / 90 ) ,和NSCLC不同组织学类型、病理分级、PTNM分期、性别、年龄及远处转移无关 (P >0 0 5 ) ;nm2 3 H1的阳性表达与淋巴结转移呈负相关 (P <0 0 1) ,与NSCLC患者术后生存期呈正相关 (P <0 0 5 )。结论 nm2 3

Objective To study the correlation between expression of nm23-H1 gene and metastasis of non-small cell lung cancer.Methods Using immunohistochemical staining SABC method, tissue sections from 90 cases with NSCLC were investigated for expression of nm23-H1.Results The positive expression rate of nm23-H1 was51.1%(46/90), and it had no relation with age, sex, histopathologic type and the metastasis of other organs (P>0.05), but had negative correlation with lymph node metastasis (P<0.01) and had positive correlation with the patient's survival time(P<0.05).Conclusion nm23-H1 is an important index to lymph node metastasis in NSCLC and prognosis.