D-二聚体检测在急性白血病合并DIC诊治中的意义

The significance of examining D-dimer in diagnosis and therapy of acute leukemia complicated with disseminated intravascular coagulation.

目的 探索D 二聚体 (D D)检测在急性白血病 (AL)合并弥散性血管内凝血 (DIC)诊断和疗效判断中的价值。方法 采集 2 0例正常对照及 5 1例无DIC、2 2例疑诊DIC、16例合并DIC的AL患者的血浆样品 ,用ELISA方法检测D D水平。结果 血浆D D水平从正常对照组、无DIC的AL组、疑诊DIC的AL组至合并DIC的AL组逐渐升高 ,各组间有显著性差异。疑诊为DIC的AL患者D D水平高者易发生DIC。随着DIC的纠正AL患者D D水平明显下降。结论 血浆D D水平检测不仅对AL所合并的DIC的诊断和早期诊断是敏感而特异的指标 ,也是其疗效观察的有用指标。

Objective To demonstrate the value of D-dimer(D-D) measurement in diagnosis and therapy of acute leukemia(AL) complicated with disseminated intravascular coagulation(DIC).Methods Plasma samples from 20 normal control, 51 AL patients without DIC, 22 AL patients with suspected DIC and 16 AL patients with DIC were examined for D-D by using ELISA.Results The plasma D-D levels increased gradually from normal control, AL patients without DIC, AL patients with suspected DIC to AL patients with DIC. There were significant differences among these groups. The patients with high D-D levels among AL patients with suspected DIC were easier to suffer from DIC than those with low D-D levels. With correction of DIC,the plasma D-D levels of AL patients decreased significantly.Conclusion Plasma D-D level is not only a sensitive and specific index for diagnosis and early stagediagnosis for DIC caused by AL, but also a useful judging index for therapeutic effect of it.