血清甘胆酸对HBsAg无症状携带者肝脏早期损害的评价

Evaluation of Early Liver Damage of ASC by Serum Cholyglycine (CG)

采用放射免疫法对生化肝功能正常的１９８例ＨＢｓＡｇ无症状携带者、２２例无症状而有胆道疾病史者和２１３例正常对照的血清甘胆酸（ＣＧ）和ＨＢＶ标记物进行检测并对结果进行统计分析。结果：①ＨＢｓＡｇ无症状携带者血清ＣＧ和有胆道疾患史组的异常率（分别为７６．２６％、７２．７２％）明显高于对照组（０．９８％）（μ分别为３．３７和１２．０５，Ｐ均＜０．０５）；大三阳组（９２．５５％）明显高于小三阳组（６１．５３％）（μ＝５．１２，Ｐ＜０．０５）；②大三阳组（９１．９６±３５．４８ｍｇ／Ｌ）明显高于小三阳组（３３．０８±１２．４６ｍｇ／Ｌ）（Ｑ＝３２．０３，Ｐ＜０．０５）。结果表明：ＨＢｓＡｇ无症状携带者肝脏比正常人群更易受到早期损害；大三阳者肝脏早期损害程度比小三阳更为严重，且发生异常更为常见。

This study is to explore the relationship between the concentration of serum cholyglycine (CG) and early liver damage in asymptomatic carriers (ASC) of HBsAg. The CG and the HBV label in serum were measured by radioimmunoassay in 198 ASC,22 ABC with historyof of biliary disease and 213 healthy subjects as control,The results showed :1).The abnormal rate of serum CG was 76.26% in ASC,and 72.72% in ASC with history of biliary disease, being significantly higher than that in healthy controls (0.98%) (3.37 and 12.05. P <0.05).2).The concentration of CG in the group of ASC with HBsAg(+), HBeAg(+) and HBcAb(+)(91.96±35.48 mg/L) was significantly higher than that with HBsAg(+),HBeAb(+) and HBcAb(+)(33.08±12.46 mg/L)( Q =32.03, P <0 05).The results indicated that ASC of HBsAg were easier to suffer from early liver damage,which was more serious amd frequently seen in ASC with HBsAg(+), HBeAg(+) and HBcAb(+) than in those with HBsAg(+), HBeAb(+) and HBcAb(+).