虫草菌粉对致敏豚鼠肺功能和大鼠气道炎症反应的影响

Effects of Fermented Cordyceps Powder on Pulmonary Function in Sensitized Guinea Pigs and Airway Inflammation in Sensitized Rats

目的 :探索人工发酵虫草菌粉防治支气管哮喘方面的新用途。方法 :测定肺功能和肺灌流液中嗜酸性粒细胞变化。结果 :虫草菌粉 5 g·kg-1对致敏豚鼠抗原攻击引起的肺阻力增高和动态肺顺应性降低以及致敏大鼠肺灌流液中嗜酸性粒细胞增多都有明显抑制作用 (P <0 .0 5 )。结论

Objective:To study Cordyceps (artificial fermented Cordyceps sinensis(Berk.)Sacc ) powderin the treatment of asthma in the animal models. Method:Pulmonary function and airway inflammation in vivo were investigated. Result:Cordyceps , 5g·kg -1 (ig), significantly inhibited bronchial challenge of ovalbumin induced change of R L and C dyn ( P <0.05) and inhibited antigen induced increase of eosinophils in the BALF of rats ( P <0.05). Conclusion:The results suggested cordyceps could be applied for the prevention and cure of asthma.