糖痹康胶囊治疗糖尿病周围神经病变临床研究

Clinical observation of Tangbikang capsule in treatment of peripheral nervous lesion owing to diabetes

目的 观察糖痹康囊治疗糖尿病周围神经病变的临床疗效。方法 糖尿病周围神经病变患者１２４例随机分为治疗组和对照组，治疗组６６例，予糖痹康胶囊，每次８粒，每日 ３次，早、中、晚饭后服；对照组 ５８例予维生素 Ｂ１２０ ｍｇ，维生素 Ｂ１２５０ｍｇ，卡马西平 １００ ｍｇ，均每日 ３次。２组均用药８周，观察２组疗效和检测２组治疗前后神经传导速度变化。结果 治疗组和对照组总有效率分别为 １００％和 ６２．１％，２组比较有显著性差异（Ｐ＜０．０１）；治疗组治疗后神经传导速度与治疗前比较有显著性差异（Ｐ＜０．０１），而对照组治疗前后则无显著性差异（Ｐ＞０．０５）。结论 糖痹康胶囊治疗糖尿病周围神经病变疗效确切。

Objective To evaluate the effect of Tangbikang capsule in treatment of peripheral nervous lesion owing to diabetes. Methods 124 patients of peripheral nervous lesion owing to diabetes were randomly allocated to two groups. In treatment group ( n = 66) patients were treated with Tangbikang capsule (8 pills three times a day) , and in control group ( n = 58) Vitamin Bl, Vitamin B12 and carbamazepine were taken, with duration of 8 weeks. Changes of nerve conductive velocity were measured before and after treatment. Re-Sults The total effective rate was significantly higher in treatment group (100% ) compared with those in control group (62.1%, P <0.01). Change of nerve conductive velocity before and after treatment in treatment group was obvious ( P < 0.01), though there was no significant difference between before and after treatment in control group ( P > 0.05). Conclusions Tangbikang capsule has a definite therapeutic effect on peripheral nervous lesion owing to diabetes.