硝苯地平缓释固体分散体颗粒的制备

Preparation of sustained release solid dispersion granules of nifedipin

目的:制备难溶性药物硝苯地平缓释固体分散体以便提高生物利用度。方法:采用固体分散技术(溶剂法)制备固体分散体,并进行体外释放度研究。结果:药物体外释药行为符合Higuchi方程;缓释结果与PVA用量和固体分散体的粒径有主要关系。

Objective: Sustained release solid dispersion of nifedipin ,which is sparingly water-soluble,was prepared toincrease the drug bioavailability. Methods: The solid dispersion was prepared by the solvent method and nifedipin release in vitro was investigated. Results: The release profiles of the drug were fitted to Higuchi model. Conclusion: Prolongation of the drug release was primarily associated with amount of PVA and particle size of solid dispersion.