培哚普利对原发性高血压病人内皮功能的影响

Effect of Acertil on endothelial function in essential hypertensive patients

提要 目的:研究新一代血管紧张素转换酶抑制剂培哚普利对原发性高血压(EH)病人内皮功能的影响。方法:观察45例EH病人(EH组)用培哚普利治疗前后的血小板聚集功能、抗氧化能力的变化,并与20例正常人(对照组)对比分析。结果:①培哚普利治疗前,EH组血小板最大聚集率、血浆血栓素B2(TXB2)和丙二醛(MDA)均明显高于对照组(P<0.05);血浆超氧化物歧化酶(SOD)明显降低(P<0.05);②培哚普利治疗两个月后,EH组血小板最大聚集率,TXB2及MDA水平均较治疗前明显降低(P<0.05),SOD水平明显升高(P<0.05);③培哚普利降压总有效率为82.2%。结论:培哚普利在有效降压的同时,不仅能抑制血小板聚集,增加机体抗氧化能力,而且还可以逆转内皮功能障碍,因而对EH病人的靶器官具有保护作用。

Objective: To observe the effect of Acertil on endothelial function of essential hypertensive patients.Method:The platelet aggregation,antioxidation and the effect of Acertil intervention were observed in 45 essentialhypertensive(EH) patients. Twenty healthy subjects were designed as control. Result:1 Maximum platelet aggregation rate andthe contents of plasma TXB2 and MDA of EH patients were significantly higher than those of the healthy subjects, whereas the contents of SOD of EH patients were significantly lower than those of the healthy subjects (P<0.05);2 Maximum plateletaggregation rate and the contents of TXB2, MDA of these patients decreased significantly, while the contents of SOD increased significantly after two months of Acertil treatment. Conclusion: Acertil can decrease blood pressure,inhibit the plateletaggregation and enhance the antioxidation. Besides these functions, it can improve the endothelial function, with its goodprotective effect on target organs of EH patients.