5%环孢菌素霜治疗亚急性湿疹及银屑病的疗效观察

为评估外用环孢菌素制剂治疗亚急性湿疹及寻常型银屑病的疗效及安全性。采用随机、双盲与基质对照的方法,观察5％环孢菌素霜对二者的疗效。61例亚急性湿疹和30例银屑病患者,分为2组,外用5％环孢菌素A霜或基质,前者:为治疗组,后者为对照组。对亚急性湿疹,治疗组有效率为27.58％,对照组12.5％,结果无显著性差异(P>0.05);银屑治疗组有效率为26.7％,对照组为20.0％;治疗过程中未发现明显副作用。

To evaluate the efficacy and safety of topical application of 5% cyclosporin A (CyA) cream for treatment of subacute eczema and psoriasis vulgaris,a randomized, double-blind and vehiclecontrolled trial was conducted in sixty-one cases of subacute eczema and thirty cases of psoriasis vulgaris. The patients were arranged into the thera-puticd and control groups. 5% CyA cream and vehicle were topically applied in the former and the later,repectively. In subacute eczema, the efficacy of 5% CyA cream was 27. 53% ,while the vehicle was 12.50% .showing no statistical significance (P>0.05); In psoriasis vulgaris, the results were 26. 70% and 20. 00% , respectively. No serious side-effects were found during the observation.