胃癌术中腹腔内灌洗化疗和腹膜内注射化疗的应用

Application of intraoperative intraperitoneal perfusion chemotherapy and injection chemotherapy for gastric cancer

目的 探讨胃癌术中腹腔内温热灌洗化疗 (intraperitonealhyperthermicperfusionchemotherapy ,IHPC)加腹膜内注射化疗对胃癌术后腹膜转移和生存期的影响。 方法 将胃癌患者5 8例随机分成A、B两组 ,A组单行手术治疗 ,B组行手术加IHPC及丝裂霉素 活性炭混悬液(MMC CH)腹膜内注射 ,观察两组病人术后的并发症及 1、3年生存率。结果 A组 1年生存率为86 .6 7% ,B组为 85 .71% ,P >0 .0 5。A组 3年生存率为 36 .6 7% ,B组为 5 7.14 % ,P <0 .0 1。两组病人术后 3年生存率之间的差异有显著性 ,但两组病人术后并发症之间的差异无显著性。结论 胃癌手术中辅以IPHP及腹膜内注射化疗对于防治胃癌的腹膜淋巴转移、腹膜复发 ,提高生存率有重要价值。

Objective To explore the effect of intra operative intraperitoneal hyperthermic perfusion chemotherapy (IHPC) and intraperitoneal injection with MMC CH on the postoperative metastatic rate and survival rate.Methods 58 patients who suffered from gastric cancer were randomized into two groups.Group A,30 patients only being treated by operation, was the control group while group B, 28 patients received intra operatire IHPC and injection chemotherapy with the MMC CH intraperitoneal.Side effects and survival rate in 1 year and 3 years were recorded. Results 1 year survival rate was 86.67% in group A, 85.71% in group B,P>0.05.3 year survival rate was 36.67%(A) and 57.14%(B),P<0.01. There was no significant difference in side effects between the two groups.Conclusion The combination with the IHPC and injection with the MMC CH intraperitoneal may prevent peritoneal metastasis and improve the survival rate.